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Fig. 6 | Alzheimer's Research & Therapy

Fig. 6

From: The autocrine motility factor receptor delays the pathological progression of Alzheimer’s disease via regulating the ubiquitination-mediated degradation of APP

Fig. 6

Effects of AMFR on learning and memory behaviors of APP/PS1 mice. A Experimental design and treatment schedule to assess the effect of Flag-AAV9-AMFR in the behavior and memory of APP/PS1 mice. 6-month-old APP/PS1 mice were injected bilaterally in the hippocampus with 1 µg of Flag-AAV9-AMFR or Flag-AAV9-Ctrl. B Mean escape latency of mice in the Morris water maze test within a 5-day training period. (WT, n = 7; APP/PS1-Flag-AAV9-Ctrl, n = 7; APP/PS1-Flag-AAV9-AMFR, n = 7). Data are shown as mean ± SEM from three independent experiments (*P < 0.05, ***P < 0.001). C Swimming time in the target quadrant of mice within a probe-test period. (WT, n = 7; APP/PS1-Flag-AAV9-Ctrl, n = 7; APP/PS1-Flag-AAV9-AMFR, n = 7). Data are shown as mean ± SEM from three independent experiments (*P < 0.05). D Number of crossings over the original platform site within a probe-test period. (WT, n = 7; APP/PS1-Flag-AAV9-Ctrl, n = 7; APP/PS1-Flag-AAV9-AMFR, n = 7). Data are shown as mean ± SEM from three independent experiments (*P < 0.05, **P < 0.01). E Swimming speed of mice within a probe-test period. (WT, n = 7; APP/PS1-Flag-AAV9-Ctrl, n = 6; APP/PS1-Flag-AAV9-AMFR, n = 7). Data are shown as mean ± SEM from three independent experiments (ns, not significant). F Representative swimming trajectories of mice in the Morris water maze probe test. G Discrimination index of mice in relation to the novel and familiar objects during the testing phase (WT, n = 7; APP/PS1-Flag-AAV9-Ctrl, n = 7; APP/PS1-Flag-AAV9-AMFR, n = 7). Data are shown as mean ± SEM from three independent experiments (*P < 0.05). H Exploration time of mice in relation to novel and familiar objects during the testing phase of the novel object test. (WT, n = 7; APP/PS1-Flag-AAV9-Ctrl, n = 7; APP/PS1-Flag-AAV9-AMFR, n = 7). Data are shown as mean ± SEM from three independent experiments (ns, not significant, *P < 0.05). I Representative motion traces of mice during the testing phases in the novel object test. J Representative heatmap images of mice during the testing phases in the novel object test

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Alzheimer's Research & Therapy

ISSN: 1758-9193