Figure 2

β-amyloid deposits in the brains of APP/PS1 mice. (a), (b) High-power images of β-amyloid (Aβ) deposits in the cortex. β-amyloid deposits are identified with anti-β-amyloid antibody (clone 4G8) (red). (c), (d) Low-power images of β-amyloid deposits in the cortex. Red dots are β-amyloid deposits. (e) Quantification of β-amyloid deposits in the cortex. (f), (g) High-power images of β-amyloid deposits (red) in the hippocampus. (h), (i) Low-power images of β-amyloid deposits (red) in the hippocampus. (j) Quantification of β-amyloid deposits in the hippocampus. Note that β-amyloid burdens both in the cortex and hippocampus are significantly decreased by stem cell factor and granulocyte colony-stimulating factor (SCF+G-CSF). Cell nuclei are stained with 4',6-diamidino-2-phenylindole (DAPI) (blue). Data presented as mean ± standard error. *P < 0.05. Scale bar: (b) 100 μm (for images in (a), (b), (f) and (g)); (d), (i) 200 μm (for images in (c), (d), (h) and (i)).